IGF Type 1 Receptor

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.

Also Known As:

IGF 1 Receptor; Receptor, IGF Type 1; IGF-1 Receptor; Insulin-Like-Growth Factor I Receptor; Receptor, IGF Type 1 alpha Subunit; Receptor, IGF Type 1 beta Subunit; Receptors, IGF-1; Receptors, Insulin-Like-Growth Factor I; IGF I Receptor; IGF-1 Receptors; Insulin Like Growth Factor I Receptor; Receptor, IGF I; Receptor, IGF-1; Receptors, IGF 1; IGF-I Receptor; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor I; Receptor, Insulin-Like Growth Factor Type 1

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        IGF Type 1 Receptor: 1243
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        IGF Type 1 Receptor: 1243
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Somatomedin Receptors: 522
        IGF Type 1 Receptor: 1243
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        IGF Type 1 Receptor: 1243

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Disease

Drug/Important Bio-Agent (IBA)